Inflammation-induced vasoconstrictorhyporeactivity is caused by oxidative stress

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Inflammation-induced vasoconstrictor hyporeactivity is caused by oxidative stress.

OBJECTIVES We sought to determine the role of oxidative stress in the development of vascular dysfunction in inflammation. BACKGROUND Hyporeactivity to catecholamines and other vasoconstrictors is present in acute inflammation. Because oxidative stress plays a significant role in inflammation, impaired responsiveness may be overcome by anti-oxidants. METHODS In randomized, double-blind, cro...

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ژورنال

عنوان ژورنال: Journal of the American College of Cardiology

سال: 2003

ISSN: 0735-1097

DOI: 10.1016/j.jacc.2003.06.002